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Lab News
2017
2018
2019
2020
2021
05
[Trends in Pharmacological Sciences] Machine Learning for Biologics: Opportunities for Protein Engineering, Developability, and Formulation
[Chemical Science] Sequestration within biomolecular condensates inhibits Aβ-42 amyloid formation
06
[Advanced Healthcare Materials] Rapid Characterization and Quantification of Extracellular Vesicles by Fluorescence-Based Microfluidic Diffusion Sizing
10
Our polymeric droplets made it to ETH Top 5 Spark Award 2021
2022
02
[Advanced Materials] Programmable Zwitterionic Droplets as Biomolecular Sorters and Model of Membraneless Organelles
05
[Nature Communications] Dynamic arrest and aging of biomolecular condensates are modulated by low-complexity domains, RNA and biochemical activity
09
Congratulations to Carolina on the ACTIP Fellowship Award and the ISEV2022 Scholarship. She has shown the potential of our zwitterionic coacervates for EV isolation and concentration.
The work led by Harini on Artificial Intelligence for development and delivery of biologics is in the top read articles of Molecular Pharmaceutics ("Design of Biopharmaceutical Formulations accelerated by machine learning", Mol. Pharm., 2021 [https://doi.org/10.1021/acs.molpharmaceut.1c00469]
We welcome the new group members Marcell, Michael, Marcos, Kasia and we are looking forward to working with them
06
Congratulations to Miriam for being awarded a Postdoc.Mobility Fellowship of the Swiss National Science Foundation (SNSF)! We wish you all the best and we are all looking forward to seeing the development of your exciting research in the Shorter Lab at University of Pennsylvania, USA.
11
[Small] High-Yield Separation of Extracellular Vesicles Using Programmable Zwitterionic Coacervates
12
Congratulations to Carolina Paganini for securing a highly competitive SNSF BRIDGE grant! This scheme supports talented young researchers to develop applications based on their research results. Looking forward to the development of your brilliant ideas!
Congratulations to Marcell Papp for the Willi-Studer Prize in the Master’s degree programme in Chemical and Bioengineering! The prize is awarded every year to the best graduates in each Master’s degree programme.
[Journal of Pharmaceutical Sciences] Surface-Induced Protein Aggregation and Particle Formation in Biologics: Current Understanding of Mechanisms, Detection and Mitigation Strategies
[Advanced Healthcare Materials] High-Yield Production of Extracellular Vesicle Subpopulations with Constant Quality Using Batch-Refeed Cultures
2023
08
[Journal of Pharmaceutical Sciences] Comparison of the Protective Effect of Polysorbates, Poloxamer and Brij on Antibody Stability Against Different Interfaces
[Analytical Chemistry] Multiparametric Orthogonal Characterization of Extracellular Vesicles by Liquid Chromatography Combined with In-Line Light Scattering and Fluorescence Detection
10
[Nature Chemistry] The interface of condensates of the hnRNPA1 low-complexity domain promotes formation of amyloid fibrils
[JACS] α-Synuclein Aggregation Is Triggered by Oligomeric Amyloid-β 42 via Heterogeneous Primary Nucleation
Dr. Ana I. Benítez-Mateos joined the lab as SNSF Ambizione Group Leader.
People
Current Group Members
Prof. Dr. Paolo Arosio
Dr. Ana Isabel Benites Mateos
Dr. Lenka Faltová
Dr. Marcos Gil Garcia
Dr. Katarzyna Makasewicz
Dr. Francesca Torrini
Dr. Carolina Paganini
Dr. Jacopo Cardellini
Dr. Suiying Ye
Dr. Xiaomei Li
Philippe Lenzen
Dominik Zürcher
Karl Normak
Chiara Morelli
Florence Stoffel
Charlotte Seiffert
Marcell Papp
Timo Schneider
Isabel Waibel
Sofia Hutter
Jonathan Garlipp
Alumni
Research
Non-equilibrium biomolecular condensates
Biomolecular condensates: from biology towards materials
Advanced biologics: antibodies and extracellular vesicles
Developability and Formulation of therapeutic proteins and antibodies
Scalable production and isolation of extracellular vesicles
Machine Learning approaches for biotherapeutics
Microfluidic technology
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